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＂超级细菌＂——产NDM-1肠杆菌科细菌感染及对策 被引量：1

＂Superbug＂——New Delhi metallo-beta-lactamase-1 in Enterobacteriaceae： challenge and strategy
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摘要 最近受到媒体广泛关注的所谓＂超级细菌（superbug）＂实际上是一种产新发现的碳青霉烯酶--新德里金属β-内酰胺酶-1（New Delhi metallo-beta-lactamase-1,NDM-1）的肠杆菌科细菌,产此酶的NDM-1基因（blaNDM-1）常见于大肠埃希菌、肺炎克雷伯菌及阴沟肠杆菌等,已在南亚发现高度耐药的感染病例,受到医学界高度重视.
作者 马亦林
机构地区 浙江大学医学院附属第一医院传染病诊治国家重点实验室
出处 《中华临床感染病杂志》 CAS 2010年第5期257-258,共2页 Chinese Journal of Clinical Infectious Diseases
关键词 肠杆菌科 新德里金属β-内酰胺酶-1 碳青霉烯酶 抗药性 Enterobacteriaceae New Delhi metallo-betalactamase-1 Carbapenemases Drug resistance
分类号 R446.5 [医药卫生—诊断学]
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参考文献8

  • 1Yong D,Toleman MA,Giske CG,et al.Characterization of a new metallo-β-lactamase gene,blaNDM-1,and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.Antimicrob Agents Chemother,2009,53(12):5046-5054.
  • 2Health Protection Agency.Multi-resistant hospital bacteria linked to India and Pakistan.Health Protection Report,2009,3(26):3-4.
  • 3Centers for Disease Control and Prevention(CDC).Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase-United States,2010.MMWR Morb Mortal Wkly Rep,2010,59(24):750.
  • 4Kumarasamy KK,Toleman MA,Walsh TR,et al.Emergence of a new antibiotic resistance mechanism in India,Pakistan,and the UK:a molecular,biological,and epidemiological study.Lancet Infect Dis,10(9):597-602.
  • 5Rose WE,Rybak MJ.Tigecycline:first of a new class of antimicrobial agents.Pharmacotherapy,2006,26(8):1099-1110.
  • 6Centers for Disease Control and Prevention(CDC).Guidance for control of infections with carbapnem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities.MMWR,2009,58:256-260.
  • 7Clinical and Laboratory Standards Institute.Performance standards for antimicrobial susceptibility testing; twentieth informational supplement.Wayne,PA:Clinical and Laboratory Standards Institute,2010.
  • 8Deshpande P,Rodrigues C,Shetty A,et al.New Delhi metallo-βlactamase(NDM-1)in Enterobacteriaceae:treatment options with carbapenems compromised.J Acad Physicians India,2010,58:147-150.

同被引文献8

  • 1李军红,田胜尼,方晓光,傅永红.5种常见中草药的抑菌性研究[J].生物技术通报,2006,22(C00):395-399. 被引量：15
  • 2Klevens RM, Morrison MA, Nadle J, et al. Inva- sive methicillin-resistant staphylococcus aureus infections in the United States [ J ]. JAMA, 2007, 298(15) : 1763 -1771.
  • 3Yong D, Toleman MA, Giske CG, et al. Charac- terization of a new metallo-{beta}-Iactamase gene, blaNDM-1, and a novel erythromycin es- terase gene carried on a unique genetic struc- ture in Klebsiella pneumoniae sequence type 14 from India [J]. Antimicrob Agents, 2009, 53 (12) : 5046 - 5054.
  • 4Wang R, Braughton KR, Kretschmer D,et al. I- dentification of novel cytolytic peptides as key virulence determinants for community-associated MRSA[J]. Nat Med, 2007, 13(12): 1510 -1514.
  • 5Kumarasamy KK, Toleman MA, Walsh TR, et al. Emergence of a new antibiotic resistance mecha- nism in India, Pakistan, and the UK: a molecu- lar, biological and epidemiological study [J ]. Lan- cet Infect Dis,2010, 10(9) : 597 -602.
  • 6Centers for Disease Control and Prevention (CDC). Detection of enterobacteriaceae isolates carrying metallo-β-lactamase-1 in the United States, 2010[J ]. MMWR Morb Mortal Wkly Rep, 2010, 59(24) : 750.
  • 7曹兰秀,顿宝生.试从中药配伍的特殊性谈中药复方药动学研究[J].陕西中医,2008,29(1):96-98. 被引量：7
  • 8王瑞君.几种中草药对金黄色葡萄球菌体外抑制作用的研究[J].现代食品科技,2009,25(9):1104-1106. 被引量：25

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中华临床感染病杂志
2010年 第5期

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