Lipo PGE_1在蛛网膜下腔出血中的应用

Effects of microspheres incorporation prostaglandin E_1 in subarachnoid hemorrhage

目的:观察前列腺素E1脂微球载体制剂(Lipo PGE1)对蛛网膜下腔出血的疗效。方法:自发性蛛网膜下腔出血患者65例,随机分为治疗组和对照组。治疗组静脉滴注Lipo PGE1,同时行其他传统治疗方法。对照组不使用LipoPGE1,其余治疗措施同治疗组,观察治疗前后影像学、血浆和脑脊液中生化指标等方面的改变。结果:两组预后存在显著差异,治疗组预后较佳(P<0.05);在出血后第3、7天,治疗组内皮素水平也明显低于对照组;两组的再出血发生率及死亡率差异无统计学意义(P>0.05)。结论:前列腺素E1能减少蛛网膜下腔出血后脑血管痉挛,改善预后。

Objective：To investigate the effects of microspheres incorporation prostaglandin E1（Lipo PGE1） in subarachnoid hemorrhage（SAH）.Methods：65 cases with SAH were divided into control group（treated with nomal drugs） and Lipo PGE1 treatment group（treated with nomal drugs and Lipo PGE1） in random.Changes in neuroimaging and some biochemical indexes was measured.Results：A better prognosis was found in treatment group（P0.05）,with a lower rate of cerebral va sospasm（P0.05）,while no significant difference in the rate of mortality and rehemorrhage was identified between two groups（P0.05）.The level of endothelin（3rd,7rd） in treatment group was lower than control group.Conclusion：Lipo PGE1 can decrease cerebral vasospasm and alleviate the neurological deficit after SAH.