妊娠期糖尿病患者糖筛查时机选择的研究

Best time of glucose challenge test for patients with gestational diabetes mellitus

目的:探讨妊娠期糖尿病患者适当的葡萄糖筛查(GCT)时机。方法:回顾性分析182例妊娠期糖尿病(GDM)患者的资料,根据GCT的时间分为孕早期组(A组)53例、孕中期组(B组)94例和孕晚期组(C组)35例,观察GDM发生的时间和最终的妊娠结局。结果:GDM主要发生在孕18～32周,而发生的高峰期为24～28周,占82.7%。妊娠结局显示妊娠期高血压、羊水过多、胎膜早破、早产、剖宫产、巨大胎儿、重度窒息、新生儿呼吸窘迫综合征、低血糖及围生儿死亡等,A组和B组间差异无统计学意义(P>0.05);而明显低于C组,差异有统计学意义(P<0.05)。结论:妊娠期糖尿病患者的糖筛查时机以妊娠中期最佳。

Objective：To investigate the appropriate sugar gestational diabetes screening（GCT） time.Methods：A retrospective analyzed of 182 cases of gestational diabetes mellitus（GDM） patients with information,according to GCT of the time,were divided into early pregnancy group（group A） in 53 cases and second trimester group（group B） in 94 cases and lasty pregnancy group（group C） in 35 cases,GDM occurred at a time and observe the final outcome of pregnancy.Results：GDM occurred in 18 to 32 weeks gestation,the peak occurs at 24 to 28 weeks,82.7%.Pregnancy outcome showed gestational hypertension,polyhydramnios,premature rupture of membranes,premature delivery,cesarean section,macrosomia,severe asphyxia,neonatal respiratory distress syndrome,hypoglycemia and perinatal death,group A and group B no significant difference（P0.05）;but significantly lower than C group,the difference was statistically significant（P0.05）.Conclusion：The best fime of glucose challenge test for patients with gestational diabetes mellitus is in the period of mid-pregnancy.