非肥胖多囊卵巢综合征患者血清hsCRP的变化与相关因素分析

The factors associated with serum hsCRP levels in normal weight women with polycystic ovary syndrome

目的:研究多囊卵巢综合征(PCOS)患者超敏C-反应蛋白(hsCRP)的变化与胰岛素抵抗、高雄激素血症、收缩压、舒张压、腰围等指标的关系,确定与PCOS患者血清hsCRP相关的因素。方法:选取PCOS患者19例,正常月经周期健康女性17例,受试者进行体重指数(BMI)、腰围、收缩压、舒张压的测量;抽取血样测定hsCRP、性激素、总胆固醇、三酰甘油、HDL、性激素结合球蛋白等;葡萄糖耐量试验、血糖钳技术检测胰岛素敏感性,比较PCOS患者hsCRP变化与胰岛素抵抗、高雄激素血症、收缩压、舒张压、腰围等指标的关系,确定与PCOS患者血清hsCRP水平相关的因素。结果:PCOS患者血清hsCRP水平高于健康组,调整BMI后差异显著性仍然存在。PCOS患者血清hsCRP水平与腰围、收缩压、舒张压呈正相关,和胰岛素介导的葡萄糖摄取(IMGU)呈负相关。BMI、收缩压和IMGU可以预测PCOS患者血清hsCRP水平。结论:PCOS本身并不增加患者血清hsCRP水平,但已知的与心血管疾病相关的危险因素如BMI、收缩压、舒张压和IMGU影响PCOS患者血清hsCRP水平。

Objective： To study polycystic ovary syndrome （PCOS） patients with high sensitive C-reactive protein （hsCRP） changes and insulin resistance, hyperandrogenism, systolic blood pressure, diastolic blood pressure, waist circumference and other indicators of the relationship, identify with PCOS serum hsCRP relevant. Methods： 19 cases of PCOS patients with normal menstrual cycle, healthy women, 17 cases subjects were body mass index （BMI）, waist circumference, systolic and diastolic blood pressure measurement; collected blood samples measured hsCRP, sex hormones, total cholesterol, triglyceride, HDL, sex hormone binding globulin; glucose tolerance test, insulin sensitivity and glucose clamp technology to compare changes in hsCRP in patients with PCOS and insulin resistance, hyperandrogenism, systolic blood pressure, diastolic blood pressure, waist circumference and other indicators of the relationship, identify patients with PCOS serum hsCRP levels relevant. Results： PCOS patients with serum hsCRP levels than healthy controls, after adjustment of BMI were significant differences still exist. PCOS patients with hsCRP levels and waist circumference, systolic and diastolic blood pressure was positively correlated, and insulin-mediated glucose uptake （IMGU） negative. BMI, systolic blood pressure, and IMGU hsCRP could predict the level of PCOS patients. Conclusion： PCOS itself does not increase the serum hsCRP level, but the known risk of cardiovascular disease-related factors such as BMI, systolic blood pressure, diastolic blood pressure and serum hsCRP IMGU level of PCOS.