胰岛β细胞的分子核医学显像进展

Progress in molecular nuclear medicine imaging of pancreatic beta cells

糖尿病是严重威胁人类健康的常见病和多发病.糖尿病主要是由于胰岛β细胞选择性破坏或胰岛e细胞分泌胰岛素迟缓和胰岛素抵抗而使胰岛素相对不足所致.β细胞的数量只有减少50%～60%时才会出现相关的症状.由于胰腺位置较深,β细胞含量少,目前临床诊断主要采用有创性方法,且难于进行早期诊断.因此,通过无创性的方法进行β细胞相关代谢疾病的早期诊断,越来越受到人们的关注,影像学诊断也就成了关注焦点,但是如何进行β细胞数量和功能的评估仍是目前影像学诊断面临的重要课题.

Diabetes mellitus is a common and frequently occurring disease which seriously threaten the health of human beings. Type 1 and type 2 diabetes respectively results from being destroyed and insufficient beta-cell mass. The associated symptoms appear until 50%-60% decrease of beta-cell mass. Because pancreas is deeply located in the body, with few beta-cell mass, the current methods of clinical diagnosis are invasive and late. So diagnosis of metabolism disease of beta-cell early and non-invasively becomes more and more popular, imaging diagnosis of diabetes mellitus becomes the focus of researches, but how to estimate the mass of beta-cell is still an important subject in imaging technology.