摘要
糖尿病肾病（DN）是终末肾功能衰竭的主要原因，主要的病理改变是肾小球肥大、细胞外基质积聚以及。肾小球硬化。多种机制参与了DN的发生、发展，其中肾脏被炎性反应细胞如单核／巨噬细胞浸润是DN的标志之一。单核细胞趋化蛋白-1（MCP-1）是一种对单核细胞具有特异趋化功能的细胞因子，参与单核／巨噬细胞的浸润，在DN的发生、发展中起重要作用。
Diabetic nephropathy is the main reason leading to end-stage renal failure, the main pathological changes are glomerulus hypertrophy, accumulation of extracellular matrix and glomerulosclerosis. Many factors are involved in the development of diabetic nephropathy, and inflammatory cells, such as mono- cyte/macrophage infiltration in the kidney is one of symbols of diabetic nephropathy. Monocyte ehemoattractant protein-1 （MCP-1） is a kind of cytokines that exhibits most potent chemotactic activity toward monocytes. MCP-1 is suggested to be implicated in the development and progression of diabetic nephropathy by playing a role in infiltration of monocyte/macrophage.
出处
《国际内分泌代谢杂志》
2010年第6期408-410,共3页
International Journal of Endocrinology and Metabolism
基金
基金项目：辽宁省高等学校科研基金资助项目（2008800）
辽宁省自然科学基金资助项目（20072093）
