医用可吸收止血材料的功能化改性研究进展

Progress in functional modification of typical biomedical absorbable hemostatic agents

介绍了国内外常用的生物医用可吸收止血材料(包括氧化纤维素或氧化再生纤维素、纤维素醚、壳聚糖、纤维蛋白胶等)的功能化改性及其应用,并对这些止血材料负载凝血酶、钙离子、多聚磷酸盐等的促凝血改性、与各种抗菌药物结合的抗菌改性和其他改性分别进行了介绍;最后对生物医用可吸收止血材料的功能化改性发展趋势进行了总结和展望。

In this paper, the functional modification and application of typical biomedical absorbable hemostatic agents including oxidized cellulose or oxidized regenerated cellulose, cellulose ethers, chitosan, fibrin glue commonly used at home and abroad, are introduced, with the emphasis on the modification of the hemostatic agents to promote clotting loaded by thrombin, calcium, polyphosphatcs and so on, and the modification to enhance the antibacterial properties combined with different kinds of antibiotics and other antibacterial drugs. Finally, the development tendency of functional modification for biomedical absorbable hemostatic agents is summarized and looked-out.