甲状腺上皮样血管内皮瘤临床病理及分子生物学特点分析

Analysis of Clinical Pathology and Molecular Biology Characteristics of Thyroid Epithelioid Hemangioendothelioma

为探讨甲状腺上皮样血管内皮瘤的病理形态特征、免疫表型和鉴别诊断,对2例甲状腺上皮样血管内皮瘤进行临床资料分析、随访,并观察其病理形态及免疫组织化学染色分析。2例甲状腺上皮样血管内皮瘤均位于甲状腺下极,实性,切面暗红色,镜下由增生的血管内皮细胞构成,具有上皮样细胞形态,胞浆较丰富,嗜酸性,多呈空泡状,细胞间可见血管腔,免疫组化:CD34(+)、Vim(+)、细胞角蛋白(cytokeratin,CK)(-)、甲状腺球蛋白(thyroid globulin,TG)(-)。上皮样血管内皮瘤是一种罕见的甲状腺肿瘤,其生物学行为属于低度恶性。

In order to investigate pathological morphology,immunophenotype and differential diagnosis of epithelioid hemangioendothelioma,and clinical data of two cases of epithelioid hemangioendothelioma were analyzed and followed up visit the two cases of patients,and investigated immunohistochemistry result.Both of two cases epithelioid hemangioendothelioma located in the lower pole of thyroid,solid,and the incisal surface was dark red.It was constituted by hyperplastic vascular endothelial cells in light microscope and had the shape of epithelioid cells which had plentiful cytoplasm,acidophilia,mostly vacuolar,with lumen among cells,the results of immunohistochemistry were CD34（＋）、Vim（＋）、CK（-）、TG（＋）.Epithelioid hemangioendothelioma was a scarce thyroid neoplasm,and its biological behaviour was low potential malignancy.