麦门冬合千金苇茎汤效应部位的化学成分

Chemical Constituents of Maimendong plus Qianjin Weijing Decoction

目的:研究麦门冬合千金苇茎汤效应部位的化学成分。方法:采用有机溶剂提取,反复硅胶柱色谱和重结晶法进行分离纯化,根据化合物的理化性质和波谱数据鉴定其结构。结果:从麦门冬合千金苇茎汤乙酸乙酯部位分离得到12个化合物,分别鉴定为:芒柄花素(formononetin,1)、甘草素(liquiritigenin,2)、异甘草素(isoliquiritigenin,3)、20(R)-人参皂苷Rg3[20(R)-ginsenoside Rg3,4]、丁二酸(succinic acid,5)、异香草酸(isovanillic acid,6)、尿嘧啶(uracil,7)、琥珀酸酐(succinicanhydride,8)、甘露醇(D-mannitol,9)、对羟基苯甲酸(p-hydroxybenzoic acid,10)、β-谷甾醇(β-sitosterol,11)、豆甾醇(stig-masterol,12)。结论:所得成分大部分来源于甘草、人参、半夏、苇茎;根据文献报道分析,其中化合物1～4可能是该合方治疗肺癌的效应物质基础。

Objective：To study the chemical constituents of Maimendong plus Qianjin Weijing decoction.Method：The constituents were isolated by column chromatography and their structures were elucidated by physico-chemical properties and spectroscopic analysis.Result： Twelve compounds were isolated and identified as form-ononetin（1）,liquiritigenin（2）,isoliquiritigenin（3）,20（R）-ginsenoside Rg3（4）,succinic acid（5）,isovanil-lic acid（6）,uracil（7）,succinic anhydride（8）,D-mannitol（9）,p-hydroxybenzoic acid（10）,β-sitosterol （11）, stigmasterol （12）. Conclusion： Most of the constituents were come from Radix seng, Rhizoma Pinelliae and Rhizoma Phragmites, and compounds 1-4 may be responsible Glycyrrhiza, Radix Gin- for lung cancer therapeutic action of the formula on the basis of literature reports.