组胺H_3受体激动剂和拮抗剂的研究进展

The Research of Histamine H_3 Receptor Agonists and Antagonists

组胺受体激动剂和拮抗剂的研究已经有半世纪,上世纪八十年代来才取得了重大进展.目前已研究组胺H_1、H_2和H_3受体激动剂和拮抗剂.其激动剂在目前虽然没有临床应用,但它促进了拮抗剂的研究进展.H_3受体拮抗剂在20世纪80年代初才开始研究.寻找选择性高、效价强的H_3受体激动剂和拮抗剂,不仅对于H_3受体功能、分布及作用机制的研究十分重要,同时对于开发具有潜在临床应用前景的该类药物也有重要意义.

Histamine receptor agonists and antagonists have been studied half a century before the last century to 80 years has made significant progress. Currently histamine H1, H2 and H2 receptor agonists and antagonists has been studied. Although there is no clinical application of its agonist, antagonist, it promoted the research. H3 receptor antagonist began to study in the early 80s of the 20th century. Looking for high selectivity and potency of strong H3 receptor agonists and antagonists, not only for the H3 receptor function, distribution and mechanism of action is important, also have potential clinical application for the development prospects of such drugs is also important.