摘要
目的：了解乳腺癌的术后辅助化疗方案TAC（多西他赛，环磷酰胺，多柔比星，6个周期）的近期不良反应。方法：选择遂宁市中心医院普外科2007年12月-2008年12月期闷30例乳腺癌术后接受辅助化疗者，行TAC方案化疗。化疗均在术后10天进行，多西他赛75mg／m2，第一天，多柔比星50mg／m2，第一天，环磷酰胺500mg／m2，第一天，21天为一个周期，一共6个周期。记录化疗期间的不良反应，包括白细胞数减少，口腔黏膜炎，腹泻，恶心呕吐，乏力，脱发，关节肌肉疼，过敏反应。结果：化疗方案TAC白细胞数减少，恶心呕吐，乏力发生率均较高。结论：化疗方案TAC各种毒副反应发生率均较高，在乳腺癌的化疗中须谨慎小心使用。
Objective： To comprehend the Adverse event profiles of Docetaxel in combination with doxorubicin and Cyclophosphamide （TAC） in adjuvant chemotherapy of breast cancer patients after breast operation. Methods：A total of 30 patients after breast operation from December 2007 to De- cember 2008 in general surgery department in SuiNing central hospital were retrospectively analyzed, adjuvant chemotherapy initiated on the 10 day after breast operation, docetaxel 75mg/m2 in the first day, doxorubicin 50 rag/m2 in the first day, cyclophosphamide 500 mg/m2 in the first day, three weeky concurrent. Iris 6 cycles in adjuvant chemotherapy. Adverse event of chemotherapy were calendar, such as leucopenia, anemia, thrombocytopenia, nausea and vomiting, weakness. Results： The adverse event profiles of leucopenia and nausea and vomiting, weakness was higher in the TAC. Conclusionz The adverse event profiles was higher in the TAC. We must be carefully in adjuvant chemotheraov of breast cancer patients.
