超敏C反应蛋白在冠心病患者中的表达

The Expression of High Sensitivity C-reactive Protein in Patients with Coronary Heart Disease

目的探讨超敏C反应蛋白(hs-CRP)在冠心病患者中的表达.方法对327例患者行冠状动脉造影并采用免疫散射比浊法测定血清中超敏C反应蛋白的含量,根据冠状动脉造影狭窄情况分为冠状动脉正常组39例,冠状动脉粥样硬化组91例,单支病变组95例,多支病变组102例,其中后两组患者诊断为冠心病.在冠心病组又分为稳定型心绞痛组53例,不稳定型心绞痛组65例,急性心肌梗死组79例.结果血清hs-CRP水平在单支病变组与多支病变组、单支病变组与粥样硬化组、稳定型心绞痛组与不稳定型心绞痛组、不稳定型心绞痛组与急性心肌梗死组比较差异有统计学意义(P<0.05),正常组与粥样硬化组比较差异无统计学意义(P>0.05).结论超敏C反应蛋白在冠心病的发生、发展和预后过程中起重要作用,可作为反映冠状动脉粥样硬化程度的敏感指标.

Objective To discuss the expression of high-sensitivity C-reactive protein（hs-CRP）in patients with coronary heart disease.Methods Totally 327 patients who had undergo coronary angioplasty and investigated the level of hs-CRP by immune scatter turbidimetry were divided into the normal vessel group（n=39）,coronary atherosclerosis group（n=91）,single vessel disease group（n=95）,and multiple vessel disease group（n=102）,the latter two groups were diagnosed with coronary heart disease（CHD）,which were divided into the stable angina pectoris group（n=53）,unstable angina pectoris group（n=65）and acute myocardial infarction group（n=79）.Results There were significant differences between single vessel disease group and multiple vessel disease group,single vessel disease group and atherosclerosis group,stable angina pectoris group and unstable angina pectoris group,unstable angina group and acute myocardial infarction group.But there was no significant difference between normal vessel group and coronary atherosclerosis group.Conclusion Hs-CRP plays an important role in the pathogenesis,development and prognosis of coronary heart disease,which would be a sensitive indicators for assessing coronary atherosclerosis degree.