COX-2 mRNA在宫颈腺癌组织中的表达及临床意义

The expression and clinical significance of COX-2 mRNA in adenocarcinoma of the uterine cervix

目的 检测COX-2 mRNA在正常宫颈及宫颈腺癌组织中的表达情况,探讨其在宫颈腺癌发病机制中的作用.方法 采用RT-PCR方法,检测COX-2在36例宫颈腺癌组织及15例正常宫颈组织中的表达.结果 宫颈腺癌组织中COX-2-mRNA的阳性检出率为55.6%,明显高于正常宫颈组织20.0%,差异有统计学意义（P＜0.05）,COX-2 mRNA的表达随宫颈腺癌期别及病理分级的升高而增加,但各期别和各病理分级之间差异无统计学意义（P＞0.05）.结论 宫颈腺癌组织中存在COX-2过表达,COX-2的过表达与宫颈腺癌的发生有关.

Objective To detect COX-2 mRNA in cervical cancer and normal cervix, and explore the pathogenesis of adenocarcinoma of the uterine cervix. Methods COX-2 expression was detected by RT-PCR to explore the relationship between COX-2 and the adenocarcinogenon of cervical cancer in 36 cases of adenocarcinoma of the uterine cervix and 15 cases normal cervical tissue. Results The positive rate of COX-2 mRNA in adenocarcinoma of the uterine cervix tissues （55.6%） was higher than that of normal tissues （ 20. 0% ）, the difference was significant （ P ＜ 0. 05）. The expression of COX-2 mRNA was associated with stages and clinical grading of tumor （ P ＜ 0. 05）, but no significant difference was found between stages and clinical grading of uterine cervix adenocarcinoma（ P ＞ 0. 05）. Conclusion The hyper expression of COX-2 mRNA in uterine cervix adenocarcinoma took part in the carcinogenesis of tumor.