微卵巢刺激Mini-IVF、玻璃化冷冻及冷冻胚胎移植

Minimal ovarian stimulation(mini-IVF),vitrification and frozen embryo transfer

为提供更自然的体外受精（IVF）治疗，Mini—IVF方案不断改进。在这非寻常的方案中，使用克罗米酚（雌激素拮抗剂）提高垂体卵泡刺激素（FSH）的分泌来刺激卵巢。克罗米酚持续使用超过5d可以抑制黄体生成素（LH）峰。与传统的IVF治疗方案比较MiniIVF卵泡数量少，手术室和实验室工作量减少，许多操作可以更轻松地完成，因此更为便宜。传统IVF方案有可能发生过度刺激并发症、

Mini-IVF has several advantages over conventional IVF protocols, including less medication and fewer injections, fewer eggs produced but eggs of higher quality. Furthermore, vitrification technique contributes to the increased IVF success rates. In this series, patients were not denied treatment based on their day3 FSH value or ovarian reserve. Yet very acceptable pregnancy rates were achieved （20% for fresh single embryo transfers and 40% for frozen single embryo transfers）. These results strengthen the argument for mini-IVF protocol and vitrification in preference to standard conventional IVF stimulation protocols. Randomized control trials are required.