结直肠癌伴梗阻病人新辅助化疗与营养支持的作用

The effect of neoadjuvant chemotherapy and nutritional support in treatment of colorectal cancer with obstruction

目的:观察新辅助化疗在结直肠癌伴梗阻病人中的作用。方法:选取结直肠癌伴梗阻的病人16例,按改良FOLFOX6方案给予新辅助化疗2个疗程,间隔2周,并同时按照肠道功能情况给予肠外或肠内营养支持,化疗结束后2周内予以手术治疗。结果:所有病人在接受新辅助化疗后梗阻均得到了不同程度的缓解。所有病人均接受了一期切除吻合手术,术后恢复良好,无并发症发生。结论:在结直肠癌伴梗阻病人的治疗中,新辅助化疗可以缓解梗阻,为一期切除吻合手术创造条件。

Objective： Colorectal cancer patients with obstruction are difficult to treatment.To avoid the risk of fistula,patients usually are forced to accept the stoma and second operation.We tried to administer the neoadjuvant chemotherapy in these patients and observed the effect of neoadjuvant chemotherapy in treatment of colorectal cancer with obstruction. Methods： 16 colorectal cancer patients with obstruction were included.They were treated with neoadjuvant chemotherapy according modified FOLFOX6 regimen for two cycles after admission.The parenteral or enteral nutrition support was administrated according to the condition of the gut function.The operations were performed within two weeks after neoadjuvant chemotherapy. Results： The obstruction was relieved in all 16 patients after neoadjuvant chemotherapy.All patients accepted the operation without any complications.Conclusion： Neoadjuvant chemotherapy can relief the obstruction resulted from colorectal cancer,and create the condition for anastomosis.