iCare回弹式眼压计与Goldmann压平眼压计测量结果的比较

Comparative study on iCare rebound tonometer and Goldmann applanation tonometer

目的对比iCare回弹式眼压计(RBT)与Goldmann压平眼压计(GAT)测量眼压的一致性,评价RBT测量眼压的准确性及安全性。方法研究为诊断性试验评价。分别用2种眼压计测量角膜正常的患者52例104眼,其中男28例,女24例;年龄19～76岁,以GAT眼压值作为基准分为5组:≤10mmHg、11～20mmHg、21～30mmHg、31～40mmHg、≥41mmHg组。评估2种测量方法的眼压值差值及其与眼压的关系。对RBT眼压值随GAT眼压值变化的关系进行评价。结果 RBT测得的眼压读数为(17.20±9.13)mmHg,GAT测得的眼压读数为(17.13±8.94)mmHg,二者差异无统计学意义(t=0.260,P=0.795)。60.58%的患者2种方法测得的眼压差值在1mmHg以内。5个组中,GAT眼压与RBT眼压的绝对差值随着眼压读数的增高而加大,最大值在≥41mmHg组,二者的最大绝对差值<4mmHg。RBT眼压读数随着GAT眼压读数的改变而变化,二者的变化呈现良好的相关性(r=0.917,P<0.01),但与GAT测量法比较,RBT测得的眼压值均稍高。当GAT眼压值>21mmHg时,RBT测量的敏感度和特异度分别为95.5%和98.8%。RBT测量后25%的患者主诉有异物感和眼干。结论 iCareRBT测量眼压具有良好的耐受性和安全性,与GAT测量眼压具有较好的相关性,适用于临床。

Background Elevated intraocular pressure（IOP）is a risk factor for the development and progression of glaucoma.Therefore,measuring IOP is essential to the diagnosis of glaucoma and monitoring of treatment.Goldmann applanation tonometry is known as the gold standard for measuring IOP in clinic.ObjectiveThis clinical trial tried to assess the agreement of IOP measured by iCare rebound tonometer（RBT）and Goldmann applanation tonometer（GAT）and compare their accuracy and safety.MethodsIOP was measured with RBT and GAT respectively in 104 normal eyes of 52 patients with the mean age 48 years old（range 19-76）.The patients were divide into ≤10mmHg（Group Ⅰ）,11-20mmHg（Group Ⅱ）,21-30mmHg（Group Ⅲ）,31-40mmHg（Group Ⅳ）,≥41mmHg（Group Ⅴ）according to the IOP readings of GAT.The statistical difference of IOP readings obtained by RBT and GAT were compared using the paired t test,and the correlation between RBT readings and GAT readings was assessed using linear regression correlation analysis.The oral informed consent was obtained from each patient prior to this trial.ResultsIOP readings obtained by RBT was 17.20±9.13mmHg,and that by GAT was 17.13±8.94mmHg without significant difference between them（t=0.260,P=0.795）.60.58% patients showed the IOP difference within 1mmHg between the two methods.The absolute IOP difference was gradually large as the increase of IOP readings with the largest value in ≥41mmHg group.The largest difference value between the two methods was less 4mmHg.The IOP readings from RBT varied as GAT with a good correlation（r=0.917,P0.01）,but the readings measured by RBT showed a slightly overestimated tendency in comparison with those of GAT.The sensitivity and specificity of RBT was 95.5% and 98.8% respectively when GAT IOP was 21mmHg.Foreign body sensation and ocular dryness were complained in 25% patients（26 of 104）after measured with RBT.ConclusionRBT is well tolerated and safe.RBT appears to correlate well with GAT in IOP measurement,and it could be useful in clinical application.