辅助性药物诱导玻璃体后脱离的研究进展

Research advances on assisted drug induced posterior vitreous detachment

玻璃体视网膜交界面的状态与许多玻璃体视网膜疾病的发生发展密切相关。近年来研究表明,玻璃体切割术前应用药物可使玻璃体液化或使许多增生性玻璃体视网膜疾病玻璃体内的纤维增生膜溶解,解除玻璃体后皮质与视网膜内界膜之间的粘连,形成完全性玻璃体后脱离,不但有利于手术的进行而且有利于玻璃体视网膜疾病的治疗和视力的恢复。本文对目前药物诱导玻璃体后脱离的组织结构、药物的作用机制及其在临床和实验研究方面的进展作简要综述。

The status of vitreoretinal interface is closely related to many vitreoretinal diseases.Recently,it has been known that drugs are utilized to liquefy the vitreous gel or dissolve of fibroplasias membrane of the vitreous body before vitrectomy,which many result in separation of the posterior vitreous cortex from the inner limiting membrane,a condition known clinically as complete posterior vitreous detachment.It is not only conductive to facilitate vitreous surgery effectively but also beneficial to the treatment of vitreoretinal diseases.This article reviews researches on relevant drugs induced posterior vitreous detachment,including the pathobiology of the vitreoretinal junction,mechanism of action,their clinical and experimental studies.