长期以小剂量阿司匹林治疗致上消化道出血的危险因素

Risk factors for upper gastrointestinal hemorrhage induced by long-term low- dose aspirin

目的：筛选长期以小剂量阿司匹林治疗致发生上消化道出血的危险因素.方法：回顾性分析本院心血管、消化科132例长期接受小剂量阿司匹林治疗患者,采用多因素非条件 logistic回归模型分析其发生上消化道出血的危险因素.结果：经过logistic回归模型分析,高血压、幽门螺杆菌（H.P）感染、年龄、饮酒史及吸烟史（按贡献大小）5个变量是长期小剂量阿司匹林治疗患者发生上消化道出血的危险因素.结论：对于长期小剂量阿司匹林治疗的患者随着年龄的增加应特别注意其有较高的上消化道出血风险,应控制血压,根除H.P,戒酒,戒烟,减少危险因素的聚集发生.

Objective： To screen the risk factors of long-term low-dose aspirin treatment induced upper gastrointestinal hemorrhage. Methods： We retrospectively analyzed 132 patients who underwent long-term low-dose aspirin. A multiple factor unconditional logistic regression model was employed to analyze the risk factors of long- term low-dose aspirin in treating upper gastrointestinal hemorrhage. Results： According to logistic regression analysis ,5 risk factors of upper gastrointestinal hemorrhage were as follows, ranged according to their pathogenic importance： hypertension, helicobacter pylon （HP） infection, age, drinking history and smoking history. Conclusions：As age increases, people undertaking long-term low-dose aspirin treatment should pay more attention to the risk of upper gastrointestinal hemorrhage. They are advised to control their blood pressure, eradicate HP, stop drinking and smoking so as to avoid the aggregation of risk factors.