蛋白激酶C在心肌纤维化中的作用

The function of protein kinase C in myocardial fibrosis

心肌纤维化是多种心脏疾病发展的共同结果,心肌成纤维细胞的增殖导致细胞外基质蛋白代谢紊乱,引起心肌重塑,最终导致恶性心律失常、心功能衰竭、甚至心脏性猝死的发生。有效地抑制心肌重塑可预防猝死的发生。明确蛋白激酶C(protein kinase C,PKC)对心肌纤维化的调控机制,可能为逆转心肌重塑提供新的治疗靶点。

Myocardial fibrosis is the common results of the development of a variety of heart diseases which leads to extracellular matrix protein metabolic disorders and causes cardiac remodeling owing to cardiac fibroblasts proliferation,eventually results in malignant arrhythmia,heart failure,and even the occurrence of sudden cardiac death.Effective inhibition of myocardial remodeling could prevent the occurrence of sudden death.To know the protein kinase C（PKC） effective mechanism of regulation on myocardial fibrosis,a new therapeutic target for reversing myocardial remodeling might be provided.