类风湿关节炎与动脉粥样硬化的相关性研究

Clinical study on correlations of atherosclerosis and rheumatoid arthritis

目的利用高频超声探讨类风湿关节炎(RA)与亚临床型动脉粥样硬化病变之间的相关性。方法超声测量45例RA患者及25例正常对照组颈动脉内-中膜厚度(IMT)及肱动脉血流介导的血管舒张(FMD),并进行对比分析。结果 RA患者颈动脉IMT较正常对照组明显增厚(P<0.01);RA组FMD较正常对照组明显降低(P<0.01)。结论 RA与动脉粥样硬化的发生有明显相关性,高频超声可作为早期预测RA患者亚临床型动脉粥样硬化有效的、敏感且无创的手段。

Objective To evaluate the correlation between subclinical atherosclerosis and rheumatoid arthritis （RA） by high-resolution ultrasonography.Methods Carotid artery intima-media thickness（IMTc） and brachial arterial flow-mediated dilation（FMD） were studied by ultrasound in 45 patients with RA and 25 normal controls.Results IMTc in patients with RA was thickness significantly than that of normal group（P 0.01） .FMD of the brachial artery in patients with RA was low significantly than that of normal group（P 0.01） .Conclusion Atherosclerosis is related to rheumatoid arthritis.High-resolution ultrasonography may be considered as a promising,sensitive and non-invasive tool for assessing subclinical atherosclerosis in RA patients in early stage.