老年人良性前列腺增生与心血管疾病的关系

Analysis of clinical characteristics of benign prostatic hyperplasia and the correlation between BPH and cardivascular diseases in the elderly

目的 了解老年良性前列腺增生（BPH）患者临床特点及用药情况,探讨BPH与心血管疾病的关系. 方法 搜集本院老年病科100例BPH患者临床资料,采用国际前列腺症状评分表（IPSS）、生活质量量表（QOL）对患者进行评价,所有患者均详细询问心血管病史,并检测前列腺特异性抗原（PSA）水平,采用腹部超声测量前列腺体积（PV）. 结果 老年BPH患者PV和PSA随年龄增长而升高;疾病严重程度以中度（IPSS 8～19分）多见;BPH患者高血压、冠心病和糖尿病患病率高,冠心病者PV显著高于非冠心病者（P＜0.05）;我院BPH患者服用5-α还原酶抑制剂和α-受体阻滞剂者多见,治疗依从性好. 结论 老年BPH患者严重程度与年龄、冠心病发病相关;药物干预治疗以5-α还原酶抑制剂使用率最高.

Objective To realize the clinical characteristics and treatment strategies in elderly patients with benign prostatic hyperplasia （BPH）, and investigate the correlation between severity of BPH and cardiovascular diseases. Methods One hundred consecutively referred patients with BPH were enrolled in this study, and the international prostate symptom score （IPSS） and quality of life （QOL） scores were recorded. All patients were queried in detail about history of cardiovascular disease, and underwent detection of prostate specific antigen （PSA） levels, prostate volume （PV） measurement by abdominal ultrasound. Results PV and serum PSA level increased with age. Forty-eight percent of patients had a moderately enlarged prostate （IPSS 8 19）. Patients with BPH had higher incidence of hypertension, diabetes, as well as coronary artery disease （P〈0.05）. The most common medical treatments were 5α- reductase inhibitors and α-receptor blockers in our hospital and most patients had good compliance. Conclusions The severity of BPH is correlated with age and morbidity of coronary artery disease. For the drug intervention therapy, 5α-reductase inhibitors have the highest utilization rate.