急性有机磷农药中毒患者血清肌钙蛋白Ⅰ和胱抑素-C的变化及临床意义

Variation and clinical significance of serum CTn and Cys-C in patients with acute organophosphorus pesticid poisoning

目的:探讨急性有机磷农药中毒(AOPP)患者血清心肌肌钙蛋白-I(CTnⅠ)和胱抑素-C(Cys-C)的改变及临床价值。方法:采用酶连免疫吸附反应(ELISA)法和全自动生化分析仪检测109例AOPP患者的血清CTnⅠ浓度和Cys-C浓度,并将100例健康体检者作为对照组进行比较。结果:AOPP组中毒后1 d、3 d、5 d时的血清CTnⅠ和Cys-C水平显著高于对照组,相比较有显著性差异(P<0.05);血清CTnⅠ和Cys-C水平随着中毒程度加重而升高。结论:AOPP患者的病情与血清CTnⅠ和Cys-C水平的变化密切相关,AOPP患者血清CTnⅠ和Cys-C水平的升高对心肌和肾脏受损具有重要的诊断意义。

AIM： To explore the variation and clinical significance of serum CTnⅠ and Cys-C in patients with acute organophosphorus pesticid poisoning（AOPP）.METHODS： The serum CTnⅠlevel in 109 patients with AOPP was tested using ELISA and the serum Cys-C level was tested using automatic biochemical analyzer,and 100 healthy subjects were used as controls group.RESULTS： After poisoning 1 d,3 d and 5 d,the serum CTnⅠand Cys-C levels of the AOPP group were higher than the controls group,compared difference was significant（P0.05）;The serum CTnⅠ and Cys-C levels increased with increasing degrees of poisoning.CONCLUSION： The degrees of poisoning of the AOPP patient is closely related to CTnⅠand Cys-C levels.When the serum CTnⅠadn Cys-C levels of the AOPP group increased,the degrees of heart and kidney damage are serious,which is important diagnostic significance for heart and kidney damage.