摘要
目的:观察慢性阻塞性肺疾病(COPD)患者血清IL-8、IL-10、α-HBDH、CRP及NO水平变化,探讨其在COPD发生发展中的意义。方法:分别检测98例COPD患者和30例健康对照者血清中IL-8、IL-10、α-HBDH、CRP及NO的水平。结果:COPD组血清IL-8、α-HBDH、CRP及NO水平明显升高,而IL-10水平明显降低,与对照组比较差异有统计学意义(P<0.05)。随着COPD分级的不断增加,血清IL-8、α-HBDH、CRP及NO水平逐渐增高,IL-10水平逐渐降低(P<0.05)。结论:血清IL-8、IL-10、α-HBDH、CRP及NO水平在COPD患者中发生显著变化,并且其变化与肺功能损害程度相关。
AIM: To observe the changes of serum IL-8,IL-10,α-HBDH,CRP and NO in chronic obstructive pulmonary diseases(COPD),and discuss their significance in development of COPD.METHODS: The serum IL-8,IL-10,α-HBDH,CRP and NO were detected in 98 cases of COPD and 30 cases of healthy controls.RESULTS: The levels of serum IL-8,α-HBDH,CRP and NO were significantly higher while IL-10 was significantly lower,than those in control group(P0.05).Moreover,with the aggression of COPD,the levels of serum IL-8,α-HBDH,CRP and NO were increasing and IL-10 were degrading,gradually(P0.05).CONCLUSION: There are significant differences of serum IL-8,IL-10,α-HBDH,CRP and NO in COPD patients,and these changes are associated with the degree of pulmonary function damage.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2010年第12期1262-1263,共2页
Chinese Journal of Cellular and Molecular Immunology