慢性阻塞性肺疾病患者血清IL-8、IL-10、α-HBDH、CRP及NO水平的变化

The study of serum IL-8,IL-10,α-HBDH,CRP and NO in chronic obstructive pulmonary diseases

目的:观察慢性阻塞性肺疾病(COPD)患者血清IL-8、IL-10、α-HBDH、CRP及NO水平变化,探讨其在COPD发生发展中的意义。方法:分别检测98例COPD患者和30例健康对照者血清中IL-8、IL-10、α-HBDH、CRP及NO的水平。结果:COPD组血清IL-8、α-HBDH、CRP及NO水平明显升高,而IL-10水平明显降低,与对照组比较差异有统计学意义(P<0.05)。随着COPD分级的不断增加,血清IL-8、α-HBDH、CRP及NO水平逐渐增高,IL-10水平逐渐降低(P<0.05)。结论:血清IL-8、IL-10、α-HBDH、CRP及NO水平在COPD患者中发生显著变化,并且其变化与肺功能损害程度相关。

AIM： To observe the changes of serum IL-8,IL-10,α-HBDH,CRP and NO in chronic obstructive pulmonary diseases（COPD）,and discuss their significance in development of COPD.METHODS： The serum IL-8,IL-10,α-HBDH,CRP and NO were detected in 98 cases of COPD and 30 cases of healthy controls.RESULTS： The levels of serum IL-8,α-HBDH,CRP and NO were significantly higher while IL-10 was significantly lower,than those in control group（P0.05）.Moreover,with the aggression of COPD,the levels of serum IL-8,α-HBDH,CRP and NO were increasing and IL-10 were degrading,gradually（P0.05）.CONCLUSION： There are significant differences of serum IL-8,IL-10,α-HBDH,CRP and NO in COPD patients,and these changes are associated with the degree of pulmonary function damage.