286例恶性肿瘤患者抑郁症的疗效观察

The efficacy of anti-depression treatment on 286 patients with malignant tumor

背景与目的:抑郁、焦虑情绪是肿瘤患者常见临床表现,本研究旨在了解住院肿瘤患者抑郁、焦虑情绪的发生率,并分析影响其疗效的独立预后因素。方法:对286例肿瘤住院患者,应用汉密顿抑郁量表(Hamilton Depression Rating Scale,HAMD)、汉密顿焦虑量表(Hamilton Anxiety Scale,HAMA)进行抑郁、焦虑情绪的发生率及其相关因素和抑郁症疗效及影响因素的调查和分析。结果:肿瘤患者抑郁和焦虑的发生率分别为48.6%和20.2%,年龄较轻、文化程度较高及乳腺癌是肿瘤患者抑郁症的危险因素;性别、文化程度、肿瘤部位为中、重度抑郁干预的独立预后因素(P<0.05),女性、乳腺癌、文化程度低的患者药物疗效差。结论:肿瘤患者抑郁症发病率较高,对于抑郁症危险因素暴露者和具有不良预后因素的肿瘤抑郁症患者,应及早给予心理干预、社会支持和必要的药物治疗。

Background and purpose： Depression and anxiety are common clinical manifestation of cancer patients, this study was to analyse hospitalized cancer patients with depression, the incidence of anxiety, and to analyze the independent prognostic factors which affect the efficacy. Methods： 286 cases of hospitalized cancer patients were analyzed by the Hamilton Depression Rating Scale （HAMD） and Hamilton Anxiety Scale （HAMA） questionnaire for depression, anxiety, the incidence of the effect of relevant factors. Results： The incidence of depression and anxiety of the cancer patients were 48.6% and 20.2%, younger age, higher educational level and breast cancer patients were risk factor for depression; gender, education level, tumor location are the independent prognostic factors of moderate to severe depression intervention （P〈0.05）, women, breast cancer, low education patients have a low drug treatment level. Conclusion： The incidence of depression in cancer patients has a higher level,the depression and cancer patients who exposure to depression risk factors and have a poor prognosis factors should be given early psychological intervention, social support and the necessary medication.