有多种皮损表现的胶样粟丘疹

Colloid milium with multiple eruptions

报告1例胶样粟丘疹。患者女,52岁。眼周、舌部丘疹2年,手部角化斑1年。体格检查:双眼周可见多个直径3～5 mm的肤色和棕色丘疹,舌及下唇黏膜下散在直径2～3 mm的黄白色小结节,部分为紫红色。组织病理学检查:真皮上层许多无结构均质的嗜酸性物质,结晶紫和刚果红染色阴性。诊断:胶样粟丘疹。该病需要和原发性系统性淀粉样变性病及类脂蛋白沉积症鉴别。

A case of colloid milium of muhiple eruptions is reported. A 52-year-old woman presented with papules around the eyes and on the tongue for two years and keratotic plaque on the hand for one year. Dermatologic examination revealed multiple flesh-col- ored or brown papules from 3 to 5 mm in size around the eyes. There were multiple submucosal dome-shaped nodules distributed on the lower-lip and the ventral surface of the tongue. The nodules varied from 2 to 3 mm in size and were translucent white to yellowish in color, and a few of which were auburn, Histopathological examination showed an eosinophilic subepidermal deposition with amor- phous homogenized structure. Both crystal violet and Congo red staining were negative. The diagnosis of colloid milium was confirmed. The differential diagnosis should include primary systemic amyloidosis and lipoid proteinosis.