妊娠期肝内胆汁淤积症孕妇血清甘胆酸水平对母儿预后的影响

Effects of serum cholyglycine on the prognosis of perineonate and mother with intrahepatic cholestosis during pregnancy

目的探讨妊娠期肝内胆汁淤积症(ICP)孕妇血清甘胆酸(CG)水平对母婴结局的影响。方法回顾性分析82例ICP患者的临床资料,按CG水平分为轻型组(CG<27 mg/L)和重型组(CG≥27 mg/L),比较两组母婴相关临床资料。结果重型组胎儿羊水污染率、新生儿窒息率、新生儿低体重率、早产率、死胎率分别为44.2%、11.6%、32.6%、58.1%、7.0%,显著高于轻型组的12.8%、2.6%、10.3%、17.9%、0%,除新生儿窒息率外,差异均有统计学意义(P<0.05)。重型组孕妇剖宫产率、肝功能异常率和产后出血率分别为93.0%、76.7%、39.5%,显著高于轻型组的64.1%、28.2%、17.9%(P<0.05)。结论血清CG水平是预测ICP母儿预后的重要指标。

Objective To investigate the effects of serum cholyglycine（CG） on the prognosis of perineonate and mother with intrahepatic cholestosis of pregnancy（ICP）.Methods Data of 82 ICP cases were retrospectively analyzed.The patients were divided into two groups of A（CG27mg/L） and B（CG≥27mg/L）.The related clinical outcomes of perineonate and mother were compared.Results The incidence rates of meconium in amnion,low birth weight of infant,preterm birth and fetus death in group B were 44.2%,32.6%,58.1% and 7.0%,respectively,which were significantly higher than 12.8%,10.3%,17.9% and 0% in group A（P0.05）.The incidence rates of cesarean section,liver dysfunction and postpartum hemorrhage in group B were 93.0%,76.7% and 39.5%,which were significantly higher than 64.1%,28.2% and 17.9% in group A（P0.05）.ConclusionSerum level of CG may predict the prognosis of patients with ICP.