卵巢肿瘤组织中L-选择素的表达和临床意义

Expression and significance of L-selectin in ovarian neoplasms

目的探讨卵巢肿瘤组织中L-选择素的表达和意义。方法选择卵巢上皮性癌患者70例(A组),卵巢上皮性囊肿患者36例(B组)和20例手术切除病理证实卵巢无病变正常者(C组),采用RT-PCR和免疫组化方法检测卵巢组织中L-选择素在mRNA和蛋白水平的表达。结果 A组卵巢L-选择素的mRNA相对表达量及组织中的阳性表达率均明显高于B、C组(P<0.05)。A组随卵巢上皮性癌临床分期和组织学分级的增加,相对表达量均随之升高(P<0.05);淋巴结阳性的患者mRNA的相对表达量及组织中的阳性表达率均高于淋巴结阴性者(P<0.05)。结论 L-选择素可能在卵巢癌的发生、浸润和转移中起作用。

Objective To explore the expression and significance of L-selectin in ovarian neoplasms.Methods The expressions of L-selectin and L-selectin mRNA were detected in the ovary of 70 patients with epithelial ovarian cancer（group A）,36 cases with epithelial ovarian cystadenoma（group B） and 20 cases with normal ovary（group C） using RT-PCR and immunohistochemistry.Results The expression of L-selectin gene and the positive expression rate of L-selectin mRNA in ovarian tissues were significantly higher in group A than those in groups of B and C（P0.05）,which in group A were higher in the patients with lymph node metastasis than those without and increased as the increases of tumor staging and histological grading（P0.05）.Conclusion L-selectin may be involved in the carcinogenesis,invasion and metastasis of epithelial ovarian cancer.