冠心病稳定型心绞痛患者抑郁与血清白介素-1β水平相关

Study on serum interleukin-1β level in depressed patients with coronary heart disease

目的:研究抑郁对冠心病稳定型心绞痛患者血清白介素-1β(IL-1β)水平的影响。方法:收集2007年7月～12月住院治疗年龄≥50岁的冠心病稳定型心绞痛患者86例。根据ZUNG抑郁自评量表(SDS)评定标准分组,即冠心病伴抑郁患者62例,冠心病不伴抑郁患者24例,对两组患者的临床特征,血脂、血糖及IL-1β检测结果进行对比分析。结果:两组患者在年龄、性别构成、吸烟、饮酒、受教育程度、并发高血压病、糖尿病等之间的差异无统计学意义。冠心病伴抑郁组IL-1β水平显著高于冠心病不伴抑郁组(P<0.05)。SDS问卷积分与IL-1β呈正相关(r=0.30,P<0.01)。同时按轻、中、重程度与IL-1β相关分析也呈正相关(r=0.35,P<0.05)。两组患者血脂水平无显著性差异,且与IL-1β之间没有相关性。结论:冠心病稳定型心绞痛患者抑郁与血清IL-1β水平相关。

AIM ： To investigate the influence of depression on the serum interleukin-1β level of patients with coronary heart disease （CAD） with stable angina peetoris （SAP）. METHODS： Eighty-six patients （age ≥50 years） with CAD with SAP admitted to our department from August 2007 to December 2007 were divided into two groups by ZHUG questionnaire （SDS） scores： Group A （patients with depression, n = 62） and Group B （patients without depression, n = 24）. We analyzed the clinical data, serum lipids, blood glucose and interleukin-1β level of all patients in the two groups. RESULTS： No significant difference was found in age, gender, smoking, alcohol use, educational level, complications of hyperten- sion, and complications of diabetes. The level of interleukin-1β in patients with CHD accompanied by depression was significantly higher than in patients with CHD without depression （P 〈 0. 05 ）. Correlation analysis results showed that the SDS score was positively related to the level of interleukin-1β （ r = 0. 35, P 〈 0. 05）. No significant difference was observed in lipid level between groups and no correlation was found with interleukin-1β level. CONCLUSION： The level of interleukin-1β was positively related in CHD patients with SAP accompanied by depression.