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肛周HPV18阳性鲍温病1例 被引量:4

A Case of Perianal Bowen Disease with Infection of HPV18
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摘要 患者男,58岁,肛周红斑,逐渐隆起,伴糜烂、渗液、疼痛1年。肛周见一类圆形暗红色斑块,边界清楚,大部分不规则隆起,部分疣状增生,呈鲜红色,表面湿润,少许糜烂。触之较硬。皮损处活检组织病理示:肛周原位鳞状细胞癌(鲍温病)。人乳头状瘤病毒分型检测:HPV18阳性。治疗:广泛的病灶切除。 A 58-year-old man presented with a red and raised plaque around anus,with erosion,exudations and pain for 1 year. The lesions appeared sharply circumscribed plaque. Most of it raised irregularly,some area showed verrucous hyperplasia. The surface had a little secretions and erosion. It was hard fairly to touch. Histopathology showed squamous cell carcinoma in situ (Bowen's disease). Detection of human papillomavirus showed HPV 18 was positive. The patient underwent wide local excision.
出处 《中国皮肤性病学杂志》 CAS 北大核心 2010年第12期1145-1146,共2页 The Chinese Journal of Dermatovenereology
基金 贵州省科学技术基金(黔科合J字[2005]2060号) 贵州省优秀青年人才基金(省卫生厅D-241)
关键词 鲍温病 肛周 HPV18 Bowen disease Perianal HPV18
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参考文献6

  • 1Munoz N,Bosch FX,de Sanjose S,et al.Epidemiologic clsssication of human papillomavirus types associated with cervical cancer[J].N Engl J Med,2003,348(6):518-527.
  • 2Ikenberg H,Gissmann I.,Gross G,et al.Human papillomavirus type-16-related DNA in genital Bowen's disease and in Bowenoid papulosis[J].Int J Cancer,1983,32:563-565.
  • 3Kawashima M,Favre M,Obalek S,et al.Premalignant lesions and cancers of the skin in the general population:evaluation of the role of human papillomaviruses.J Invest Dermatol,1990,95(5):537-542.
  • 4Philip E.LeBoit,Günter Burg,David Weedon,et al.Pathology & Genetics Skin Tumours[M].France:IARCPRESS Lyon,2006:26.
  • 5徐佳,古力达丽哈·波帝,王萍.Paget样鲍温病1例[J].中国皮肤性病学杂志,2009(6):369-370. 被引量:2
  • 6Margenthaler JA, Dietz DW, Mutch MG, et al. Outcomes, risk of other malignancies and need for formal mapping procedures in patients with perianal Bowen's disease[J]. Diseases of the colon & rectum, 2004, 47(10) :1655 - 1661.

二级参考文献3

  • 1赵亮 方方 罗公超 等.多发性鲍温病伴发鳞状细胞癌及基底细胞癌1例.中华皮肤科杂志,1997,30(6):409-409.
  • 2RAJU R R, GOLDBLUM J R, HART W R. Pagetoid Squamous cell carcinoma in situ ( Pagetoid Bowen's disease ) of the external genitalia [J]. Int J Gynecol Pathol , 2003,22(2) : 127 -135.
  • 3晋红中,王家璧.Paget样鲍温病[J].临床皮肤科杂志,2004,33(6):391-392. 被引量:6

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