摘要
儿茶酚胺氧位甲基转移酶将S-腺苷蛋氨酸提供的甲基转移到多巴胺、肾上腺素、去甲肾上腺素等儿茶酚胺类的苯环上,使之降解失活.儿茶酚胺氧位甲基转移酶基因对神经递质代谢途径的参与使其成为很多精神疾病的候选基因.本文对儿茶酚胺氧位甲基转移酶基因遗传多态性与精神疾病的相关性作一综述.
The enzyme catechol-O-methyltransferase （COMT） transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine,epinephrine and norepinephrine. This methylation results in the degradation of catecholamines. The involvement of the COMT gene in the metabolic pathway of these neurotransmitters has made it an attractive candidate gene for many psychiatric disorders. This review focuses on the association between the genetic polymorphisms of COMT gene and psychiatric disorders.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
2010年第6期650-653,共4页
Chinese Journal of Medical Genetics
基金
云南省自然科学基金（2007C223M,2009CD211）
云南省教委基金（07210336）
昆明医学院研究生创新基金（KM2008J02）
