高迁移率族蛋白B1肿瘤免疫调节作用及其机制

Immune regulatory role of high-mobility group box 1 protein in tumor and the related mechanisms:recent progress

危险信号相关模式分子(DAMPs)是指能被模式识别受体识别的危险信号分子,从细胞胞内释放到胞外的高迁移率族蛋白B1(HMGB1)是经典的DAMPs,HMGB1的释放提示机体已经受到损伤。已有大量的研究证明HMGB1参与了肿瘤血管形成、凋亡抵抗、生长刺激以及侵袭转移,表明HMGB1能够促进肿瘤的发生进展。而新近有研究报道指出HMGB1具有佐剂样作用,能够增强获得性抗肿瘤免疫反应。种种研究显示HMGB1具有双向的肿瘤免疫调节作用。因此,本文主要对HMGB1的肿瘤免疫调节作用及其机制的研究进展作一综述。

Danger associated molecular pattern（DAMPs） is defined as the danger signal molecules that can be recognized by pattern recognition receptors （PRRs）.High-mobility group box 1 protein （HMGB1） belongs to DAMPs and the release of HMGB1 indicates the damage of tissues.Many researches have showed that HMGB1 participates in tumor angiogenesis,evasion of apoptosis,self-sufficiency in growth signals and invasion and metastasis,indicating HMGB1 can promote tumor development and progression.More recent findings indicate that HMGB1 can be used as an adjuvant to enhance the efficiency of the antitumor immune response.Various reports have suggested that HMGB1 plays a double phase action in tumor immunological regulation.This papers is aimed to review the role of HMGB1 in tumor immunological regulation and the related mechanisms.