微血管红细胞流动的数值化仿真

Numerical Simulation of Red Blood Cell Flow in Micro-Vessels

目的研究微血管中红细胞特性,为治疗微血管疾病和研究微流体提供依据。方法采用计算流体力学方法(CFD)来研究微血管中血液流动的特性,用连续介质方法仿真微血管中红细胞之间以及红细胞和血管壁的相互作用;用流体体积法(VOF)仿真微血管中红细胞的变形和聚集。结果通过仿真结果得出微血管中红细胞在血浆中流动特性的数值化结果。结论数值化仿真微血管中红细胞的变形,能够部分得出导致微血管疾病的原因,可对日常保健和临床诊断起到指导作用。

Objective To investigate the behavior of red blood cells in micro-vessel, which could provide evidence for curing micro-vessel diseases and the micro-vessel investigation. Methods This paper used the computational fluid dynamics （CFD） to simulate the behavior of blood flow in micro-vessel; used the continuum approach to simulate the cell-cell and cell-wall interactions, and the volume of fluid （VOF） was used to simulate the movements of RBCs in micro-vessel and predict the RBCs’ deformation. Results From the simulation in the micro-vessel, we get the numerical flow behavior of the RBCs in the plasma. Conclusion Numerical emulate the blood-flow in micro-vessel partly answers how vessel-diseases happen, so that provide available information for health keeping and clinical diagnosis.