基于相平面图分析的FCM视网膜神经节细胞响应的研究

Research on the Response of FCM Retinal Ganglion Cells with Phase Plane Analysis

目的研究视网膜神经节细胞的电特性,为视觉假体的研究提供帮助。方法利用Matlab对视网膜神经节细胞模型-Fohlmeister-Colman-Miller(FCM)模型,进行数值计算与计算机仿真,比较其在不同电流刺激下的响应,并用相平面分析方法来分析其动力学特征。结果 FCM模型产生的动作电位与实验结果相符合,FCM的5种离子通道在一个动作电位形成过程中,作用时间不同,对动作电位形成的影响不同;相平面分析表明,动作电位在各个阶段的变化速度不同,脉冲峰值的大小,不同强度的刺激电流产生的动作电位的脉冲峰值大小不同。结论通过相平面图及其它方法的直观分析,FCM视网膜神经节细胞对电刺激具有良好的电生理响应。

Objective To study the electrical characteristics of retina ganglion cells, which is more helpful to understand the stimulation strategy for retinal prosthesis. Methods The FCM model, as a kind of retinal ganglion cell model, was calculated and simulated with Matlab, the responses were compared under different electrical stimulations, and FCM model’s dynamic characteristics were analyzed with phase plane method. Results It was shown that the action potential produced with FCM model was correspondent with the result of experiment. Five ion channels in retinal ganglion cells played different roles as they acted at different time during the formation of a single action potential. FCM model generated different impulse frequencies in response to various depolarization currents. Different rate and peak values of action potentials could be seen visually in phase plane. The different peak values of action potentials were produced with different intensities of electrical stimuli. Conclusion FCM retinal ganglion cell is of good electrical physiological responses to electrical stimulation being analyzed with phase plane plot and other methods.