静息状态下海洛因成瘾者伏核功能连接的fMRI研究

Functional connectivity of nucleus accumbens in heroin addicts： a resting-state fMRI study

目的 利用静息态功能磁共振成像（fMRI）技术分析海洛因成瘾者静息状态下与伏核有功能连接的脑区,以探讨海洛因成瘾者＂奖赏系统＂的组成.方法 选择安徽省戒毒所自2009年6月至2010年3月收治的自愿接受戒毒的海洛因成瘾患者15例作为成瘾组,同期健康体检者15例为对照组,进行静息态fMRI扫描后选取左、右侧伏核为感兴趣区（ROI）进行静息态脑功能连接分析,确定受试者静息状态下与双侧伏核有功能连接的相应脑区.结果 静息状态下成瘾组中与伏核有功能连接的脑区包括双侧丘脑、基底节区、海马、中脑以及对侧伏核等脑区（左侧伏核还与前扣带回有显著的功能连接）;而对照组中与伏核有功能连接的脑区仅为海马和对侧伏核,而且激活程度明显小于成瘾组.结论 静息态下与伏核有功能连接的脑区构成了成瘾的＂奖赏系统＂;静息态fMRI技术有助于了解与海洛因成瘾相关脑区之间的功能联系.

Objective To investigate the brain areas having functional connectivity with nucleus accumbens in heroin addicts with resting-state functional magnetic resonance imaging （fMRI）, and explore the reward system of heroin addiction. Methods Fifteen participants with heroin addiction,voluntarily admitted to our drug rehabilitation center from June 2009 to March 2010, and 15 healthy controls at the same period were chosen in our study. Resting-state fMRI was performed on these patients; and then, the resting-state brain functional connectivity was also concluded by analyzing the left and right nucleus accumbens selected as regions of interests （ROIs）. The corresponding brain areas having functional connections with ROIs were defined in the resting-state and the changes of functional connectivity were observed in heroin addicts. Results In the addiction group, the areas having functional connectivity with double nucleus accumbens included bilateral thalamus, the basal ganglia, the hippocampus, the midbrain and contralateral nucleus accumbens; and anterior cingulate cortex was also significantly correlated with left nucleus accumbens. However, in the control group, only the hippocampus and contralateral nucleus accumbens had these connection and their activity was much weaker than that in the addiction group. Conclusion In the resting-state, reward system of heroin addiction is constituted by the brain areas having functional connectivity with nucleus accumbens. And fMRI can be used to study the functional connections between the brain areas related to the heroin addiction from neuroimaging perspectives.