热痹汤治疗类风湿关节炎活动期58例临床观察

Clinical Observation on 58 Patients with Active Rheumatoid Arthritis Treated by Rebi Decoction

目的观察热痹汤治疗类风湿关节炎(RA)活动期的临床疗效。方法将符合纳入标准的96例患者随机分为治疗组(服用热痹汤水煎液)58例和对照组(服用来氟米特片及中药安慰剂水煎液)38例,从临床症状(晨僵时间、关节疼痛程度及数目、关节肿胀程度及数目等)、实验室检查指标(红细胞沉降率、C反应蛋白、类风湿因子、免疫球蛋白)、安全性指标等方面评价治疗效果。结果治疗组与对照组总有效率分别为86.21%和68.42%,两组总疗效比较,治疗组优于对照组(P<0.05);两组患者在消除或减轻临床症状方面均有较好作用,而治疗组在晨僵、双手握力、20m步行时间、关节疼痛程度、关节疼痛数目、关节肿胀程度等6个方面则优于对照组(P<0.05或P<0.01);两组在恢复或改善实验室检查指标方面,除IgA之外,均有较好作用(P<0.01),且治疗组优于对照组(P<0.01)。结论热痹汤对RA活动期治疗作用显著。

Objective To observe the effect of Rebi Decoction（Decoction for Hot Bi Syndrome）on active rheumatoid arthritis（RA）.Methods The 96 RA patients meeting the standard of diagnosis were randomized into treatment group of 58 cases treated with Rebi Decoction and control group of 38 cases treated with leflunomide tablets and placebo decoction.The effect was evaluated with the indices of clinical symptoms（morning stiffness,severity and number of painful joints,severity and number of swelling joints）,lab tests such as erythrocyte sedimentation rate（ESR）,C-reactive protein（CRP）,rheumatoid factor（RF）,immunoglobulin,and safety.Results The total effective rate of the treatment group was 86.21% and that of control group was 68.42%,with significant difference between（P0.05）.In relieving the symptoms,both groups were good,while the result of relieving the morning stiffness,hands gripping,20 meters walking,severity and number of painful joints,and severity of swelling joints in the treatment group was better and that in the control group（P0.05 or P0.01）.Both groups were good in improving the above lab indices except IgA,and the treatment group was better than the control group（P0.01）.Conclusion Rebi Decoction for RA is effective.