中西医结合治疗对哮喘儿童Th1/Th2细胞因子影响的研究

Effect Of integrated traditional Chinese and western medicine on Th1/Th2 cytokines level in children with asthma

目的：探讨中西医结合对哮喘儿童Th1／Th2细胞因子影响的研究。方法：随机分为对照组和治疗组，对照组用孟用鲁司特片2—5岁4mg，6～14岁5mg，每晚1次睡前口服。治疗组在对照组基础上加中药平喘汤，每天1剂，水煎分4～6次服。共8周。另设健康儿童组做对照。治疗前后采静脉血3mL，用ELISA法检测IL-4，IL-13和IFN—γ水平。结果：治疗前两组哮喘疗患儿IL-4，IL-13水平均高于健康组，而IFN—γ水平则低于健康组，两者差异有显著性（P〈0．01，P〈0．05）。8周后治疗组IL-4，IL-13水平下降、IFN—γ水平升高，与对照组比较，差异有显著性（P〈0．05）。结论：中西医结合治疗儿童哮喘可显著下调IL-4，IL-13及上调IFN—γ水平，从而减轻气道炎症，有效地防止哮喘的发作。

Objective： To discuss the effect of integrated traditional Chinese and Western medicine on Th1/Th2 cytokines level in children with asthma. Method： Children with asthma were randomly divided into control group and treatment group. The control group was given Montelukast Sodium tablets for 4 mg （2-5 years old） or 5 mg （6-14 years old）, once every night before sleeping. At the same time, the treatment group was given Pingchuan water decoction additionally for one tie per day , in four to six-divided doses for eight weeks. On the other hand, groups of health children were selected as blank control. Before and after treatment, the level of IL-4, IL-13 and IFN-γ were detected by elisa from 3 mL of venous blood. Result： Before treatment, IL-4 and IL-13 in two groups were obviously higher than healthy group, but IFN-γ was lower （P 〈 0. 01, P 〈 0.05 ）. After eight weeks, IL-4 and IL-13 in treatment group went down, but IFN-γ increased. And there were significant different compared with the control group （P 〈 0. 05 ）. Conclusion： Treating children asthma by integrated traditional Chinese and western medicine can obviously reduce IL-4 and IL-13, increase IFN-γ, and therefore lighten the airway inflammation, prevent asthma attacks effectively.