平阳霉素治疗婴幼儿腮腺咬肌区血管瘤

Treatment of infantile hemangioma in parotid gland region with pingyangmycin injection

目的评价平阳霉素（pingyangmycin，PYM）治疗婴幼儿腮腺咬肌区血管瘤的临床疗效。方法采用PYM瘤内注射治疗婴幼儿腮腺咬肌区血管瘤12例，隔周1次，3～4次为1个疗程。1个疗程不能治愈者，间隔1个月后行第2个疗程治疗。记录不良反应及病变转归进程，追踪随访，评价临床疗效。结果10例治愈，2例显效。治愈病例中注射1次2例，注射2次3例，注射3次3例，注射4次2例。2例范围较大的血管瘤，分别注射6次和7次后瘤体基本消退，8个月后复诊，局部皮肤略呈花斑状。随访1～3年，无复发病例，无局部溃疡及明显瘢痕，无面神经损伤症状。全身不良反应表现为低热和食欲下降，无过敏病例。结论PYM瘤内注射治疗婴幼儿腮腺咬肌区血管瘤疗效确切，不损伤面神经，不形成明显瘢痕，是可取的临床治疗方式。其疗程长短与病变范围相关，提示早期治疗具有积极意义。

Objective To evaluate the clinical efficacy of pingyangmycin （PYM） injection on infantile hemangioma located in the parotid gland region. Methods Twelve patients were treated by intrale- sional injection of PYM. When necessary, the injections were repeated at an interval of one week, but not more than 3-4 sessions within a therapeutic period. Normally, the secondary therapeutic period was performed 1 month later. The general and local adverse responses were recorded and the clinical outcomes were assessed with a follow-up of 1 to 3 years. Results Complete clinical resolutions were achieved in 10 patients. 2 patients received one injection, 3 patients received 2 injections, 3 patients received 3 injections, and 2 patients received 4 injections. The remaining 2 patients with partial resolution received 6 and 7 injections respectively. No clinical recurrence was observed during the follow-up of 1 to 3 years. No ul- cerations or postoperative scars in injection regions were presented. The function of facial nerve was remained normality in all patients. The systematic side effects included transient pyrexia and poor appetite appeared in partial patients. No allergy cases were found. Conclusion Treatment of infantile hemangioma located in parotid gland region with PYM injection reveals a high rate of complete clinical resolution, with fair cosmetic results and short treatment time, and it does not damage the facial nerve or form local scar. The treatment time of PYM injection seems to be positively related to size of the lesions.