辛酸癸酸聚乙二醇甘油酯对加替沙星角膜透过性的影响

Effect of Labrasol on the corneal permeability of gatifloxacin in vitro

目的:研究辛酸癸酸聚乙二醇甘油酯(Labrasol)作为渗透促进剂对加替沙星角膜透过性的影响。方法:采用体外扩散实验考察不同浓度Labrasol对加替沙星角膜透过性的影响。结果:Labrasol质量浓度为0.5%使加替沙星的表观渗透系数增加了1.45倍,与对照组比有显著性差异(P<0.05),质量浓度为1%,1.5%,2%,3%使加替沙星的表观渗透系数分别增加了2.68,4.45,3.90和4.64倍,与对照组比都有极显著性差异(P<0.01)。结论:Labrasol能提高加替沙星的角膜透过性。

Objective：To explore the effect of Labrasol as penetration enhancer on an ocular drug delivery system.Methods：The effect of Labrasol on the corneal permeability of gatifloxacin in vitro was investigated in isolated rabbit corneas.Results：Labrasol at 0.5% improved the apparent permeability coefficient of gatifloxacin by 1.45-fold in comparison with control（P〈0.05）.Labrasol at 1%,1.5%,2% and 3% showed a significant improvement on the apparent permeability coefficient of gatifloxacin by 2.68-,4.45-,3.90-and 4.64-fold in comparison with control（P〈0.01）,respectively.Conclusion：Labrasol can enhance the corneal apparent permeability of gatifloxacin.