利伐沙班的合成

Synthesis of rivaroxaban

目的:合成高效、直接的FXa抑制剂利伐沙班。方法:以2-(2-氯乙氧基)乙酰氯、对硝基苯胺为原料,合成利伐沙班。结果:合成了利伐沙班,总收率为42.46%,纯度95.19%(HPLC)。结论:通过优化反应条件,缩短了反应时间。

Objective： To synthesize the effective and direct FXa inhibitor,rivaroxaban.Methods： Rivaroxaban was synthesized by 2-（2-chloro-ethoxy） chloride and p-nitroaniline.Results： Rivaroxaban was synthesized with a total yield of 42.46%.The purity of rivaroxaban was 95.19%（HPLC）.Conclusion： The reaction time is decreased by optimizing the reaction conditions.