多功能心腔内超声导管性能的初步测试

Initial experimental investigation of the performance of multifunctional intracardiac echocardiography catheter

目的在离体条件下重点测试自行设计研发的多功能心腔内超声导管操控性能、超声辐照换能器工作情况,实时监控心肌内注射的能力。方法分别运用精密阻抗仪及超声声功率计测试超声辐照换能器的工作频率及声功率,然后将多功能心腔内超声导管送入离体猪心左心室,并在左心室游离壁测试多功能心腔内超声导管在心肌内注射时对实时监控注射针进针深度及指导微泡注射的能力。结果该10F多功能心腔内超声导管能够实现单向弯曲;集成心腔内超声成像、心肌内注射、超声辐照和电生理标测功能,超声辐照换能器频率和声功率分别为7.2MHz和0.28W,能够实时监控进针深度及微泡分布情况。结论本研究设计的多功能心腔内超声导管可能为经心内膜药物投递提供更为安全、有效的治疗方案。

Objective To investigate the performance of a self-design multifunctional intracardiac echocardiography catheter regarding handling,ultrasound irradiation transducer and the capability of intracardiac echocardiography transducer for intramyocardial injection monitoring in vitro. Methods Precision impedance analyzer and ultrasound powermeter were used to detect the frequency and power of ultrasound irradiation transducer. Then multifunctional intracardiac echocardiography catheter was inserted into left ventricular of pig in vitro,transendocardial injection of microbubble within left ventricular wall was performed to investigate the capability of this multifunctional intracardiac echocardiography catheter on real-time injection depth monitoring. Results This multifunctional intracardiac echocardiography catheter （10F） was one way steerable which integrated intracardiac echocardiography,trasendocardial injection,ultrasound irradiation and electrophysiology mapping into a single catheter. The frequency and power of ultrasound irradiation transducer was 7.2 MHz and 0.28 W,respectively. In addition,this multifunctional intracardiac echocardiography could achieve transendocardial injection depth monitoring and provide further information on the distribution of microbubble during injection. Conclusion This multifunctional intracardiac echocardiography catheter may provide a safe and effective strategy for transendocardial injection in future.