鸦胆子油乳联合丝裂霉素治疗恶性胸腔积液的研究

The application of Yadanzhi grease combined with mitomycin in the treatment of malignant pleural effusion

目的研究鸦胆子油乳联用丝裂霉素治疗恶性胸腔积液的疗效。方法选样67例患有恶性胸腔积液的住院患者,分别胸腔内注射鸦胆子油乳、丝裂霉素与单用鸦胆子油乳、丝裂霉素,每周1次,连续注射2-3周。结果鸦胆子油乳联用丝裂霉素组治疗有效率83.3%,鸦胆子油乳组59.1%,丝裂霉素组57.1%（P〈0.05）。结论鸦胆子油乳联用丝裂霉素治疗恶性胸腔积液的疗效明显优于单用鸦胆子油乳、丝裂霉素。

Objective To observe the curative effects on malignant pleural effusion treated with Yadanzhi（YDZ） grease and mitomycin（MMC）.Methods Sixty-seven in patients suffering from malignant pleural effusion were divided into three groups randomly：24 patients in the treatment group were treated with mitomycin 6 mg and YDZ 60 ml,22 patients were treated with YDZ and 21 patients were treated with mitomycin.The doses were given one time every week,for 2～ 3 weeks.Results The total effective rates in the treatment group,YDZ group and mitomycin group were respectively 83.3%,59.1% and 57.1% respectively（P〈0.05）.Conclusion The effect of using YDZ and mitomycin together in treatment of malignant pleural effusion is superior to using only YDZ or mitomycin.