肺乳头状腺瘤临床病理观察

Papillary adenoma of the lung:Report of 1 case and literature review

目的:探讨肺乳头状腺瘤的临床病理特点。方法:应用光镜、免疫组化染色等方法对我院一例肺乳头状腺瘤进行分析,并复习文献。结果:肿瘤为分化成熟的肺泡上皮细胞构成腺管,由乳头状、团块状结构及纤维间质构成。腺管和乳头上皮多为单层排列,细胞呈立方状,核淡染,无核分裂。免疫组化示瘤细胞CK(++),TTF-1(++),间质V im entin(++),Actin(+)。结论:肺乳头状腺瘤是一种罕见的良性肿瘤,易与硬化性血管瘤、肺泡性腺瘤、乳头状腺癌混淆。

Objective： To investigate the clinicopathology features of papillary adenoma of the lung. Method： Morpholoical observation and immunohistochemistry was applied for one case of papillary adenoma of the lung, and the literatures were also reviewed. Results：The malignant cells were arranged in papillary and adenoma with the well differentiated pulmonary alveolus epithelium, cells grew with a line, the surface cells were cubic, nucles were normally stained and caryokinesis were invisible. Immunohistochemically, the tumor cells were positive for CK and TFF - 1, storomal were positive for Vimentin and Actin. Conclusions：Papillary adenoma of the lung is a rare tumor, which is easy to be confused with sclerosing and alveolar adenoma and papillary carcinoma.