阑尾类癌临床病理分析(附6例)

Carcinoid of the appendix:a clinicopathological analysis of 6 cases

目的:探讨阑尾类癌的临床病理学特点。方法:收集6例阑尾类癌临床资料,结合免疫组化方法进行研究。结果:男性4例,女性2例,发病年龄14-57岁,平均33.60岁。发生部位近端2例,中段2例,末端2例。典型类癌3例,杯状细胞类癌1例,管状类癌1例,混合性类癌-腺癌1例。神经内分泌标记物Syn、CgA、NSE癌细胞均有不同程度表达。其中3例做了右半结肠切除术并化疗,随访10-36个月,均健在。结论:阑尾类癌组织形态特殊,诊断主要依靠组织病理学与免疫组化标记结果确定。早期发现、早期诊断与手术治疗,是提高患者生存期和治愈率的关键。

Objective：To investigate the clinicopathologic characteristics of the appendiceal carcinoid. Methods： Clinicopathological analysis of 6 cases of appendiceal careinoid was performed with immunohistochemical study. Resutis： The appendiceal careinoid patients consisted of 4 males and 2 females, with the onset age ranging 14 -57 years （ median, 33.6 years） ;2 eases of proximal appendix, 2 of middle appendix, 2 of terminal appendix;3 eases of typical carcinoid, 1 case of goblet - cell carcinoid, 1 case of tubular carcinoid, 1 case of mixed carcinoid - adenocar- cinoma, neuroendocrine markers Syn, CgA, NSE expressed in tumor cells. The right - side colonectomy and chemotherapy carried out in 3 patients, who were followed up 10 -36 months, still survived. Conculsion： The histomorphology of appendieeal carcinoid is very special, can be diagnosed according to histopathology and immunohistochemistry results. The key to improve its survival and cure rates is early detection and operation.