VEGF-C、VEGFR-3在肿瘤淋巴管生成中作用的研究进展

Advances of VEGF-C and VEGFR-3 in lymphangiogenesis of tumor

血管内皮生长因子C是调节淋巴管生成的主要因子,在许多肿瘤组织中高表达,与其受体血管内皮生长因子受体3结合后,可特异性作用于淋巴管内皮,刺激淋巴上皮增殖,诱导瘤内或瘤周围淋巴管生成和/或扩张,促进肿瘤微淋巴管生成。肿瘤淋巴管生成是肿瘤转移过程中的重要条件,肿瘤细胞可通过表达淋巴管生成的调控因子VEGF-C和VEGFR-3促使淋巴管生成,促进肿瘤细胞的淋巴转移。肿瘤淋巴管生成及其对抗研究是当前肿瘤研究的热点,并有可能成为治疗肿瘤淋巴转移的靶点。二者间关系密切,且相互作用,相互影响。

Vascular endothelial growth factor - C （ VEGF formation and highly expressed in a variety of tumor tissue. - C） is the main control factor to promote lymphatic vessel Binding with its receptor - vascular endothelial growth factor - 3 （ VEGFR - 3 ）, VEGF - C exclusively stimulates epithelial proliferation, and induces lymphangiogenesis lymphatic vessel expansion, thereby promoting tumor microlymphatic generation. Tumor lymphangiogenesis is a para- mount component for tumor metastasis process. Recent experiments indicated that VEGF - C and VEGFR - 3 secreted by tumor cells were able to activate tumor lymphangiogenesis and increase lymphatic metastasis. These findings will lead lymphangiogenesis and its resistant researches to be a focus in the study of lymphatic metastasis and a possible target of therapy. Lymphangiogenesis can make impact on the tumor metastasis process, and vice versa.