盐酸丁卡因离子导入研究

Study of iontophoresis of dicaine hydrochloride

目的 :研究药物的电压与离子导入速率的关系。方法 :以盐酸丁卡因为模型药物 ,采用去毛大鼠腹部皮肤和双室扩散池 ,分别测定不同电压下的增渗倍数 (ER)。结果 :增渗倍数对电压的线性回归方程为 :ER =-3× 1 0 - 3+3 .2 0 2V ,r=0 .9979。结论

OBJECTIVE:To study the effect of voltage on drug transdermal iontophoresis.METHOD:The enhancing rate(ER) of dicaine hydrochloride with different voltage through rat skin were determined respectively using valia-chien two-chamber diffusion cells.RESULTS:linear regression show that:ER=-3×10 -3 +3.202V,r=0.9979(V is voltage).CONCLUSION:The enhancing rate is proportion to voltage.