密蒙花方改善早期糖尿病视网膜病变中医症状及其用药安全性的研究

Effects of Mimenghua Formula on TCM symptoms of early diabetic retinopathy and safety

目的评价中药复方密蒙花方对非增殖期糖尿病视网膜病变的中医症状疗效及其用药安全性。方法观察63例患者,中药密蒙花方组31例,对照羟苯磺酸钙组32例,2组患者在均接受糖尿病药物治疗的情况下,服药3个月,治疗前后定期观察患者各项中医症状指标、血液流变性指标,以及肝功能、肾功能等反映用药安全性的指标。结果密蒙花方组患者中医症状改善以及稳定无加重者明显多于对照组(P<0.01),总有效率为96.77%。服用密蒙花方患者血流变30/s切变率降低(P<0.05),未见肝肾功能下降者。结论中药复方密蒙花方能降低非增殖期糖尿病视网膜病变患者的血液黏度,改善患者全身及局部症状,未见肝肾功能损害,其用药是有效安全的。

Objective To review the curative effects and safety of Chinese medicinal compound formula-Mimenghua Formula on TCM symptoms of diabetic retinopathy in nonproliferative stage.Methods The patients（n=63） were divided into the Mimenghua Formula group（n=31） and control group（n=32）.On the base of treatment of diabetic medicinal,the Mimenghua Formula group was treated with Mimenghua Formula and the control group was treated with calcium dobesilate for 3 months.The indexes of TCM symptoms,hemorrheology,liver function and kidney function,which reflected the medicinal safety,were observed regularly before and after the treatment.Results In the Mimenghua Formula group the number of patients whose TCM symptoms were relieved and the patients were in stable condition without worse were significantly higher than those in the control group（P0.01）.The total effective rate was 96.77%.The shear rate（30/s） decreased（P0.05） and there were no patients with the decrease of liver function and kidney function in the Mimenghua Formula group.Conclusion Mimenghua Formula can reduce the blood viscosity,and relieve the whole and local symptoms in the patients with diabetic retinopathy in nonproliferative stage.There were no patients with lesions of liver function and kidney function.Mimenghua Formula is effective and safe.