摘要
目的观察补肾活血法结合西药治疗肾性骨病(ROD)的疗效。方法采用区组随机法将符合纳入标准的60例观察病例分为补肾活血组(30例)和单纯治疗组(30例)。补肾活血组给予补肾活血中药颗粒剂+综合治疗方案,单纯治疗组给予单纯综合治疗方案。服药观察周期为12周。分别于治疗前后检测每组病例血甲状旁腺激素(PTH)、骨特异性碱性磷酸酶(BAP);并采用积分方法评价中医证候学的变化情况。结果补肾活血组疗效总有效率高于单纯治疗组;补肾活血组全段PTH、BAP均明显下降,而单纯治疗组未见明显改善。结论补肾活血法结合西药治疗ROD具有较好的疗效,可以缓解ROD患者甲状旁腺功能亢进的状态,有效改善骨代谢异常。
Objective To observe the curative effect of the therapy of tonifing kidney and activating blood circulation combined with Western medicinal on renal osteodystrophy(ROD).Methods The randomized block method was used to divide 60 patients into the treatment group(n=30)treated with the granules with the actions of tonifing kidney and activating blood circulation and complicated therapeutic plan,and control group(n=30) treated with complicated therapeutic plan only.The observation period was 12 weeks.The levels of serum parathyroid hormone(PTH) and bone-specific alkaline phosphatase(BAP) were detected respectively before and after the treatment.The changes of TCM symptomatology were reviewed by using scoring method.Results The total effect rate of the treatment group was higher than that of the control group.The levels of serum PTH and BAP decreased significantly in the treatment group but not changed in the control group.Conclusion The therapy of tonifing kidney and activating blood circulation combined with Western medicinal has good curative effect on ROD,which can relieve hyperparathyroidism and treat metabolic bone disease in ROD patients.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2010年第11期782-785,共4页
Journal of Beijing University of Traditional Chinese Medicine
关键词
肾性骨病
补肾活血法
临床症状
甲状旁腺功能亢进
renal osteodystrophy
therapy of tonifing kidney and activating blood circulation
clinical symptoms
hyperparathyroidism