血栓与基因表达障碍的关系

Relationship between thrombus and hindrance of gene expression

除直接构成血栓的纤维蛋白、红细胞、白细胞、血小板之外,引起血栓的基础原因是"三高"(高脂、高糖、高血压),而造成"三高"的根本原因是基因表达障碍导致的"三低"(激素浓度低、酶浓度低、抗体浓度低),这也是代谢综合征的病因。基因表达过程需两性物质核酸和蛋白质参与,能影响两性物质的最基础物质是酸碱变化。随着人体逐年老化,体内调节缓冲酸碱的能力已衰退,加上不良生活方式、环境污染,造成人体偏酸是无可争议的。实验证实,pH值下降与基因表达产物蛋白质的生物合成浓度成正相关。

The pathogenic reason for the formation Of thrombus is the ＂Three Highs＂ （hyperlipoproteinemia, hyperglycemia,hypertension）. The basic reason for the ＂Three Highs＂ is the hindrance of gene expression which leads to the ＂Three Lows＂ （low concentration of hormones, low concentration of enzymes, low concentration of antibodies）. Two amphiphilic substances-nucleic acid and protein are involyed in gene expression and are basically affected by any changes of the pH value. As the ageing of the human body, the tactility of regulating the acid-base equilibrium declines in vivo. Furthermore maladjusted life-style and environmental pollution cause the human body to spontaneously accumulates acidic substances, promoting it to become slightly acidic. This reality is now with no dispute. Experimental results confirmed that as the pH value in the body decreased, the amount of proteins synthesized by gene expression also decreased. This result is of positive correlation.