生长抑素及P物质在胃电节律失常中的作用

Effects of Somatostatin and Substance P on Development of elecfrogastric dysrhythmias

探讨生长抑素（ＳＳ）和Ｐ物质（ＳＰ）在大鼠胃电节律失常中的作用。利用大鼠胃电节律失常模型，测量胃窦肌间神经丛中生长抑素免疫反应（ＳＳ－ＩＲ）神经和Ｐ物质免疫反应（ＳＰ－ＩＲ）神经的含量。分别记录注射ＳＳ类似物善得定（奥曲肽，Ｏｃｔ）和ＳＰ后的胃电活动。与对照组比较，实验组大鼠胃窦肌间神经丛ＳＳ－ＩＲ神经含量明显增多，而 ＳＰ－ＩＲ神经含量明显减少（ Ｐ＜０． ０５）。注射Ｏｃｔ后出现胃电节律失常，注射ＳＰ后胃电节律无明显变化，只是快波（ｆａｓｔ ｗａｖｅ）的发放明显增多。表明胃窦肌间神经丛中ＳＰ－ＩＲ神经与ＳＰ－ＩＲ神经的比例失调可能是胃电节律失常发生的重要原因之一。

To investigate the effects of somatostatin(SS)and substance P (SP)on occuring of electrogastric dysrhythmias in rats. The contents of SS immunoreactive (SS-IR ) nerves and SP-IR nerve & were studied in antral myenteric plexus in rat model of electrogastric dysrhythmias. Gastric myoelectric activities were recorded followed by injecting SS analogue,sandostatin (Octretide, Oct)and SP respectively. Compared with control,the contents of SP-IR nerves in myenteric plexus in test group rats were increased significantly,while SP-IR nerves were decreased significantly(P<O. 005). The electrogastric dysrhythmias was induced by injecting Oct,while the electrogastric rhythm was not varied significantly and fast waves increased significantly by injection of SP. The abnormal proportion of SP-IR nerves to SP-IR nerves plays a most important role in the development of electrogastric dysrhythmias in rats.