紫外线照射充氧自血回输治疗脑梗塞观察红细胞膜Na^+-K^+-ATP酶的变化

Effect of ultraviolet blood irradiation and oxygenation on acute cerebral infarction and changes of Na+-K+-ATPase on erythrocyte membrane

目的：探讨紫外线照射充氧自血回输疗法（ＵＢＩＯ）对脑梗塞治疗作用及其机制。方法：５０例急性脑梗塞患者分为治疗组和对照组，治疗组３０例用ＵＢＩＯ与传统药物联合治疗，对照组２０例仅用传统药物治疗，进行两组疗效比较，同时检测两组患者治疗前后红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶活性。结果：治疗组的总有效率为９０％，对照组为７５％，经过Ｒｉｄｉｔ法分析，两组差异有显著性（Ｐ＜０．０５）。两组患者红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶活性明显低于健康人对照组（Ｐ＜０．０１）。ＵＢＩＯ治疗１个疗程患者红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶活性比治疗前显著增强（Ｐ＜０．００１），而药物治疗组治疗前后患者红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶活性无明显变化（Ｐ＞０．０５）。结论：ＵＢＩＯ治疗脑梗塞，疗效显著。其机制可能与ＵＢＩＯ对患者红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶活性增强效应有关。

Objective: In order to study the therapeutical effect of ultraviolet blood irradiation and oxygenation (UBIO) on cerebral infarction and its mechanism. Methods: 50 patients with acute cerebral infarction were divided into two groups:the treatment group (treated with UBIO and traditional drug),and control group(treated with traditional drug only).In two groups the activity of Na+-K+-ATPase on erythrocyte membrane was determined before and after therapy. Results: The total effective rate of treatment group (90%) was significantly higher than that of control group (75%),the activity of Na+-K+-ATPase on erythrocyte membrane in patients with acute cerebral infarction was lower significanly than that of healthy persons.But after UBIO therapy the activity of Na+-K+-ATPase was increased markedly as compared with before therapy.No change after using traditional drug was found.ZConclusion: UBIO has a beneficial effect on cerebral infarction and its therapeutic effect mechanism was linked with enhancement of activity of Na+-K+-ATPase on erythrocyte membrane of patients with cerebral infarction.